effect

have an effect on somebody/something  

big/major/profound/significant/dramatic effect  

bad/harmful/negative/damaging/detrimental/adverse effect  

beneficial/positive effect long-term effect  

feel the effect of something 

 knock-on-effect British English =an effect caused by the thing that happened before  

cumulative effect =the effect of many things happening one after another 

the desired effect =the effect you wanted  

cause and effect =one thing directly causing the other